Think Bomb

Sunday, April 01, 2007

Lateralization of the cerebral hemispheres

Introduction

In grade school, I recall that the idea of being "left brained" or "right brained" was quite popular. Teachers would give us tests of our drawing or math ability to determine which half of our brain was "dominant." These days, the right is generally considered the creative and emotive half while the left is analytical and logical. These generalizations are somewhat out dated. As you will read, history has continually tried to assign concrete roles to the versatile, complex hemispheres of the brain. After talking a bit about the beginnings of our knowledge of hemispheric lateralization, I will go into some modern studies and theories about the two halves of the brain. This is a long one, so you might want to set some time aside or break it down into parts if you're reading on the fly. Enjoy!

A brief history of lateralization theories

Since the 1800's neurologists have been fascinated by the division of labor between the right and left hemispheres of the cerebral cortex. The specializations of each hemisphere have been repeatedly rewritten as new case studies and empirical data enter our understanding of cerebral lateralization.

It was 1861 when publication of Broca's breakthrough case study of a man with verbal expressive aphasia revealed the left hemisphere's dominance for language. The unfortunate gentleman had lost the ability to speak although he could still make noises and understand language. Post mortem autopsy revealed that the man had profound atrophy of the posterior portion of the second and third frontal gyri of his left hemisphere, now known as Broca's area. This area has been repeatedly confirmed as a key area involved in the motor functions necessary for speech production.

After Broca's breakthrough discovery, reports pooled in about the various disorders found in patients with left hemisphere lesions, including Wernicke's identification of receptive aphasia in 1874, Exner's identification of agraphia in 1881, and Lissauer's findings on agnosia in 1890 (Cutting, 9-12).

The left hemisphere continued to be viewed as the "verbal hemisphere" into the 1950's. As added support for the theory of left hemispheric verbal dominance, examination of epileptic patients by Miliner in 1958 found that patients undergoing a left temporal lobectomy suffered more significantly in recall of verbally spoken stories than those with removal of the right. The right was eventually dreamed the "spatial hemisphere;" Miliner's study of epileptic patients with lateralized temporal lobectomies being a large contributor to this theory. It seemed that those with the right temporal removed had difficulty identifying the scene in a picture but less difficulty with verbal recall than those who had left temporal lobectomies.

The 1960's brought new ideas regarding the distribution of labor between the hemispheres. Throughout the early 1900's it was common knowledge among physicians that the right hemisphere seemed to have a link with emotion, but the idea was not popularized until the 1960's. Again, patients of temporal lobectomies were the main influence for these generalizations. It seemed that those without the left temporal lobe tended to suffer depression while those lacking a right leaned toward euphoria or apathy. A tendency for patients with left hemisphere damage to suffer depression is still seen today (Cutting 24-26).

In the 1970's the verbal/nonverbal dichotomy lost much of its momentum as research began to show the important role of the right hemisphere in understanding metaphor and emotion in speech as well as its contribution to the fluency and tonality of language production. Instead a new dichotomy began to form in which the right hemisphere was seen as the "Gestalt" processor while the left was considered detail-oriented. This new theory mainly arose from studies of split brained patients--people who had had their corpus callosum (the connecting fibers between hemispheres) severed to control epilepsy. These patients were better able to reconstruct whole pictures (such as the circular face of a clock) with their left hand and visual field (controlled by the right hemisphere) and more able to focus on parts (such as the numbers on a clock) when working with their right hand and right visual field (controlled by the left hemisphere) (Cutting 21-23).

Today, the idea of hemispheric lateralization is so popular that terms like "left brained" and "right brained" are used (and often misused) colloquially. Although one cannot be literally left brained or right brained without sever damage or removal of a hemisphere, the terms are informally interpreted as how creative or analytical a person is. The right hemisphere is considered creative in the popular view, while the left hemisphere is known as the analytic half. There are, of course, faults to all of these extreme generalizations that have been made through the ages. Cutting notes the dilemma with this interpretation in his text, the Right Cerebral Hemisphere and Psychiatric Disorders:
"To call the left hemisphere analytic is heuristically unhelpful. It only provokes the questions--analytic of what? and how does it analyze?" -Cutting, 77

Sound and the hemispheres

To examine the known functions of the left and right cerebral hemispheres to date, let us begin with one of the first and most well known lateralizations: the distribution of verbal skills in the left and right hemispheres. Typically, the left hemisphere plays the chief role in speech production as it is the site of the Broca's and Wernicke's areas, but in a few people both hemisphere's play some role in speech production and in some left handed people the right hemisphere is dominant (containing both the Broca's and Wernicke's areas). For about ninety percent of the population though, the left hemisphere is dominant for speech (Cohen 32-33).

The idea of the left hemisphere as the verbal hemisphere arises from the many speech disorders that can be seen when portions of the left hemisphere are diseased or ablated. Verbal expressive aphasia (also known as Broca's aphasia), as mentioned earlier, is seen in patients with damage to the Broca's area. The disorder results in laborious, grammatically incorrect speech. The symptoms include difficulty with function words, such as "the," "a," "in," or "on" and slow, trying speech production. Patients are still able to produce content words, such as nouns, verbs, and adjectives. As part of the secondary motor cortex of the frontal lobe, these difficulties that result from Broca's aphasia are thought to arise from the inability to fall back upon the motor memories that the lips, tongue, and mouth rely upon for forming fluent speech.

Wernicke's aphasia is another startling condition that can arise from damage to the left hemisphere. Located in the auditory cortex of the left temporal lobe, the Wernicke's area and surrounding tissues are responsible for speech comprehension and the conversion of thoughts into meaningful speech. It is directly connected to the Broca's area by a series of axons creating a smooth connection between speech comprehension and production in unaffected people. When the Wernicke's area is damaged, fluent speech can still be produced due to the motor memory of the Broca's area, but content words are often replaced with nonsense (Carleson 482-495).

When the language areas of the left hemisphere are severely damaged, patients are sometimes able to recover lost verbal abilities in the corresponding areas of the right hemisphere. Mainly younger patients, especially those below the age of three, are able to make full recoveries (Habedank B, Haupt WF., Heiss WD., Herholz K., Kessler J., Thiel A, Winhuisen L).

The right hemisphere, too, plays a role in speech comprehension and production. It is essential for recognition of tone and the emotional expression in a speakers voice (Sander K, Scheich H). Many case studies show that lesions of the right cerebral hemisphere often result in a decreased ability to detect the emotion in another’s words. Prosody, the rhythm, emphasis, and melody of speech, is also a key role of the right hemisphere (Carlson 499-501, Young 53-54). Although speech can still be understood by those lacking the Broca's and Wernicke's areas of the left hemisphere, the right hemisphere cannot produce speech on its own in most people.

Even in the absence of actual language, the auditory processing of the hemispheres has a fundamental lateralization dependent upon the type of auditory stimulus provided. According to fMRI studies, the brain responds to increased temporal variation in sound with more dominance in the left Heschl's gyrus, while an increase in spectral variation in sound shows more activity in the right superior temporal gyrus and right posterior superior temporal sulcus (Bishop DV, Jamison HL, Matthews PM., Watkins KE).

Functional MRI studies of patients exposed to music too show lateralization. The right hemisphere seems to be more involved in interpretation of music than the left. Again, we see the right hemisphere playing a larger role in deciphering tones and rhythm. Professional musicians, on the other hand, showed a stronger left hemispheric lateralization when listening to music. It is theorized that this may be due to their analytic interpretation of the music; they already have an orderly categorical system by which to interpret the sound whereas novices do not (Huang, Chen, Wang, and Chung 187).

Visual perception in the hemispheres

It is especially difficult to define the roles of the hemispheres in visual spatial representation due to a lack of terminology and definition for different types of visual spatial abilities. Although it is fairly clear that there is a difference in the ways the hemispheres process visual spatial information, where the line is drawn as to which hemisphere does what seems to be very difficult to categorize.

Beginning with the basics, there does not seem to be a large difference in the ability of either hemisphere to detect a visual stimulus in its visual field. Several studies in the sixties and seventies including Filbey and Gazzaniga in 1960, Bryden in 1976, and Jeeves and Dixon in 1970, reported that both patients with left hemisphere damage and those with right did not have difficulty detecting light dots or other visual stimulus in their intact visual fields. A hemispheric difference in perception of visual stimulus seems first be noticed when defining the orientation of a seen object. Multiple studies show that the right hemisphere holds a superior ability to distinguish a line’s orientation to the horizontal or vertical axis (Young 8-12).

Once we move on from presenting patients with basic shapes to entire pictures new distinctions between hemispheric structures can be identified. Visual-object agnosia, caused by lesions of the left parieto-occipital region, results in an inability to identify the category to which an object belongs. Patients are still able to identify isolated elements and whole scenes, indicating that the left hemisphere is essential for the categorization of objects (Cutting 13-14, 76).

Again, much research seemed to point to the left hemisphere playing a role in identifying parts while the right perceived objects as wholes. The idea that the left hemisphere is necessary for perceiving parts creates a dilemma; how deeply can we consider an object or scene a whole or in parts? For example, I could say the forest is the whole and the trees the parts, or the tree is the whole and the branches are the parts, or the branches are the whole and the cells are the parts. At which point does the left hemisphere become responsible for identifying the pieces of the whole and the right for putting the whole together? It seems the theory that left perceives parts while the right perceives wholes is too general. A better way to describe the role of the left hemisphere might be to say that it provides the formal relationships between objects as they fall into categories and subcategories (e.g. to say that a Dodge Spirit falls into the "car" category) while the right hemisphere considers how these representations reflect the order of the actual world.

An interesting theory of how the left and right hemispheres cooperate in object recognition comes from Warrington and Taylors' 1978 experiments. They noted that the first stage in object recognition is perceptual categorization by its physical nature, in which the right hemisphere collates all possible spatial configurations of an object so that it can be perceived from any visual angle. Next, the left hemisphere adds a semantic category to the object (again supporting the idea that the left is the hemisphere of language). Her support for this theory comes from studies in which patients with right hemisphere lesions consistently have difficulty matching same objects presented from odd angles (Cutting 75-76).

Along these lines a later theory by Kosslyn in the late 80's suggested that the left and right hemispheres worked independently rather than in the serial fashion proposed by Warrington. The right could encode shapes from multiple perspectives, he suggested, while the left funneled a range of shapes into a single, symbolic representation that could be easily named (Cutting 77-80).

In addition to superiority in recognition of three dimensional objects at presented at odd angles, the right hemisphere also seems to be dominant in its ability to recognize facial expressions. This could be said to be a part of its overall excellence in Gestalt reasoning, but also might be attributed to the right hemisphere's regard as the "emotional hemisphere." (Cutting 26).

Unilateral neglect

In patients with grandiose damage to either the left or right hemisphere, paralysis of the opposite side of the body may result. Interestingly, a defense mechanism known as unilateral neglect is typically only seen in those with lesions of the right cerebral hemisphere with corresponding paralysis of the left side of the body (Cutting 36). Patients with unilateral neglect completely ignore their entire left visual field as if it did not exist. For example, they may draw a clock with only numbers on the right side, or when asked to mark where the middle of a line is they may make a mark far to the right of the middle.

As described in Oliver Sack's case studies, sometimes patients are able to understand their situation on an intellectual level, yet still have difficulty resolving the problem. One of Sack's patients, Mrs. S, suffered a massive stoke effecting the posterior regions of her right cerebral hemisphere. The result was unilateral neglect of her left visual field but after having her situation explained to her she was able to combat the obstacle by turning almost full circle to the right to recover the missing half of her meals or papers, although she was still unable to grasp the concept of turning left, as left simply did not exist to her (Sacks 77-79).

Another more extreme symptom of a lesion to the right hemisphere can be full blown denial. Patients with denial not only neglect their left visual field, but also deny the fact that they are paralyzed. In his case studies, V.S. Ramachandran describes some patients who would go out of their way to deny their paralysis. One patient, when asked of her paralyzed left hand "whose arm is this?" responded that it must be her brother's, not her own, because it appeared to be rather hairy (Ramachandran 127-133).

When damage spreads as far as ventromedial frontal lobe of the right hemisphere, denial often expands beyond the patient's paralysis and body image into other regions as well. Patients may deny any out of the ordinary behavior or situation from eating candy to the existence of a diagnosed brain tumor whereas no such problems were noted in patients with corresponding lesion in the left hemisphere (Ramachandran 142-143).

Tying it all together

A fascinating theory of lateralization that takes much of the to-date research into account comes from V.S. Ramachandran in his novel, Phantoms in the Brain. The function of the left hemisphere, Ramachandran writes, is primarily the preservation of stability. This may be why we see cases of denial and neglect in patients with right hemispheric legions but not in those with left as their left hemisphere strives to maintain the status quo. This also explains the euphoric or apathetic nature of those with right hemisphere damage; if they cannot perceive that something is wrong then they do not worry about the problem. The right hemisphere, on the other hand, is charged with assimilating novel information. Again, we see that it must take a wholesale approach instead of categorizing items into preexisting schemes. Take again, for example, visual perception. The right hemisphere must be able to recognize an object from a new angle, at this point taking in the novel information. The left hemisphere is then able to categorize this information, sorting it into the filing system of the mind. As Ramachandran jokingly suggests,
"The right hemisphere is a left-wing revolutionary generating paradigm shifts, whereas the left hemisphere is a die hard conservative that clings to the status quo"-Ramachandran, 136

In conclusion, it seems that not all is yet known about the distribution of labor between the right and left cerebral hemispheres. In the majority of the population, it appears that the left hemisphere is a place for systemic categorization, such as the parts of language and music that can be organized and the things in life which can be readily cataloged. The right hemisphere is more elusive, dealing in emotions and abstractions; it helps us to take in novel information that we do not yet have a name for.

Sources

Bishop DV, Jamison HL, Matthews PM., Watkins KE. "Hemispheric Specialization for Processing Auditory Nonspeech Stimuli." Cerebral Cortex. 10 (2005): 1093

Carlson, Neil R. Physiology of Behavior, Eighth Edition. New York: Pearson Education, Inc. 2004.

Cohen, David. The Secret Language of the Mind. San Fancisco: Chronicle Books, 1996.

Cutting, John. The Right Cerebral Hemisphere and Psychiatric Disorders. New York: Oxford Press, 1990.

Habedank B, Haupt WF., Heiss WD., Herholz K., Kessler J., Thiel A, Winhuisen L. "From the left to the right: How the brain compensates progressive loss of language function." Brain Language. (2006)

Ramachandran, V.S. and Blakeslee, Sandra. Phantoms in the Brain. New York: William and Marrow Company, Inc. 1998.

Sacks, Oliver. The Man Who Mistook His Wife for a Hat and Other Clinical Tales. New York: Touchstone, 1998.

Sander K, Scheich H. "Left auditory cortex and amygdala, but right insula dominance for human laughing and crying." Journal of Cognitive Neuroscience. 17.10 (2005): 1519

Wang, Huang, Chen, and Chung. "Monitoring Music Processing of Harmonic Chords using fMRI: Comparison between Professional Musicians and Amateurs." International Society for Magnetic Resonance in Medicine (2006): 187

Young, Andrew W. Functions of the Right Cerebral Hemisphere. London: Academic Press, 1983.

6 Comments:

  • It still irritates the crap out of me when my art instructor tells me to draw with my right brain instead of my left. I want to neatly set down the pencil and insist that I can't recreate the set in front of me on paper if I don't use both.

    -Sam

    By Anonymous Anonymous, at 6:54 PM  

  • Wow Sam, she really says that? You should lay down the law ;)

    By Blogger Kim Russo, at 9:15 PM  

  • Another fascinating essay, excellent!

    -Ryan

    By Blogger Ryan, at 3:20 PM  

  • I make lists:

    (1) I hate introductions to the topic - like your fist paragraph. While I recognize their necessity from the reader's point of view, if you consider the article as a proof of intelligence, the introduction is simply a reiteration of someone else's work (probably a longer, more thorough, and possibly better-stated introduction to the topic). So all it really shows of the author is that they can restate what somebody else said, rather than analyzing any kind of newly acquired empirical data. I kind of have contempt for that, but I do it all the time, I'm sure. From our dearly departed friend, "So it goes."
    (2) Sad for the poor asshole that his fucked up brain parts were named after his fully-competent doctor. If I was the doctor, I think I'd want the brain parts to be called the patient's name, and just let people cite my theory with the name.
    (3) "The left was eventually dreamed the "spatial hemisphere" " -- deemed? I guess in the context of the right, dreamed is quite appropriate. I absolutely love using the wrong word. I try to do it all the thyme.
    (4) How does one go about a lobectomy? Seems like it is removing a lobe. How many lobes are in the brain? Doesn't seem like that many. What about the first person -- how did he justify removing it, how did he know that removing it wouldn't just destroy the person (it probably did?)? Must have been a dire case without the brain parts removal. How do you decide which lobe to remove without opening the person's head in the first place. Maybe they based it off of the past autopsies. Seems like a pretty primitive and unconvincing solution to any problem, to me, without an history of prior success, given that the brain is significantly more diversified in function than say, the right vs. left kidney. I like that, as a court case. Right Kidney v. Left Kidney. "You stole my woman!" That sounds something more like Kennedy though.
    (5) Man, the thing about cutting the corpus callosum. I hate those words, they don't mean a damn thing. They just confuse people, but that's a different soap box. I hate jargon. Anyway, that is so weird!! I bet there are some illusions that would make me say "Whoa" like a surfer as well. I wonder if I would like this more if it was just a list of facts, numbered.
    (6) My belief about studying the brain is that it'll remain confusing and wrong for a good amount of time. The brain studying itself -- I think that the it's not intelligent enough to figure itself out. The analogy is like an ant understanding itself. I know that's not very well thought out, but I'm not looking to make neuro-crazy stuff my life.
    (7) Okay, this article kind of makes me want to get brain damage so I can know more about how *my* brain works -- somehow though, I think I'll resist the temptation. Also, as an exercise to impress women, I'd like to get brain damage and see how much ability I can recover afterward. Kind of like playing Mortal Kombat with a 100% handicap to show your skill.
    (8) Is function words a term from linguistics or neuro-crazy? I will substitute the word -crazy for all neurology, neurosurgery, neuron. And yes, the word -crazy does begin with -, and - is a letter. Ignant fool.
    (9) I remember hearing about these at some point in the past. I think you should move the section about Wernicke's area up in the article, because you mention it before, and since this is a public blog with readers from a social dating website, it's probably best if you define things before you use them in other contexts.
    (10) It's mildly scary for me to think about losing the left half of my brain. It's like losing a basket with things in it, you're not exactly sure what - they might be vital, they might not. But then afterwards, you're not even able to inventory what you've lost. Not that you can't remember, but that you can't even think about it! Your article in a sense is kind of like the Republicans, like a Caesar, I think. You keep me reading, but the whole time you are insidiously filling me with a fear, like I must keep paying attention to you so that I can know more and avoid these terrible fates, or find that as long as I ask forgiveness from Jesus, then I'll be okay. Okay it's a bit of a stretch, but it's interesting to think about for a few seconds.
    (11) I'm not sure if this article is more interesting because it helps me classify freaks, or if I am legitimately interested in how the brain works. Or rather, that I am confident that this research is really valid. This probably makes me an insensitive, bad person. Maybe I'll get brain damage for it. *Knock on wood*
    (12) I haven't read Cutting, but it seems like you'd need additional logical steps to say that not being able to recognize an object at different angles (while missing part of your brain) means that people who aren't missing parts have a little package, in their brains, of pictures of an object from all different angles. I think that these are two fundamentally different things.
    (13) These paragraphs ending with Cutting citations, I think that these people really have no idea what's going on, which is why they're using such general terminology in describing the way that things are processed in the brain.
    (14) "Left simply did not exist to her." Wow. I'm not sure precisely what that means, but it seems like a spectacular sentence.
    (15) Ha ha @ the denial. I guess that says something about dishonest people and their brains, but I'm not sure exactly what. Says something about pathological liars?
    (16) "Preservation of stability" Wow. Now *that* is vague. Maybe Ramachandran's book is fun to read though. Another one for the list.
    (17) In conclusion, I've told you some funny stories about people with brain damage, and we still don't know how the brain works, but we still engage in conceited speculation. :-). I think that'll be the ending for quite some time.
    (18) Funny to me that I have to fill in this "security word" -- it's like they are testing to see how the brain works by comparing it to the requirements you'd put an a computer trying to reproduce some function of the brain, which is pretty popular these days.


    You have a great blog. I'm really glad that it has substance. I should bookmark it. Seems like you're a pretty big target for the guys, even if you're a small target for a bomb.

    Louis

    By Blogger Louis, at 2:08 PM  

  • Louis- Please be more conscientious of hostile language and rambling in future comments as this blog is read by people who may not appreciate it and it does not add to the scientific discussion. If you are from okcupid where anything goes, please realize that this is a different kind of forum. I will not delete your comment this time. I will try to answer some of your questions/comments though. #1: Part of the reason for the layout of this entry is that it was originally composed for a class, so it is not in my usual blogging style. Sorry if this irritated you. #3: Thank you for trying to point out the errors, but deem is the word I intended to use, as in "He deemed it a good cause." #4: A lobectomy is indeed the process of removing a lobe. #7: It is true that experimental ablation is common method for understanding the brain, but I would not recommend doing it to yourself. ;)
    Thanks for reading!

    By Blogger Kim Russo, at 6:12 PM  

  • I am curious why you termed Phantoms in the Brain a novel. I read most of it and I don't really see how it can be considered a novel in the traditional sense of the word, though it is a novel piece of literature I must admit. And I used a quote from it about Kuhnian paradigm shifts in an epistemology paper I wrote a few years ago so it does have its merits (and if I remember correctly Dr. Ramachandran makes clear the speculative nature of the work as opposed to, say, Freud, which means you cannot really reproach any of his results, since he is not, as opposed to Freud, saying 'this is it').

    By Anonymous Anonymous, at 12:39 AM  

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